Lycoramine

SKU: orb1297294

Description

Lycoramine is a potent acetylcholinesterase (AChE) inhibitor isolated from Lycoris radiata. It is used in research for studying neurodegenerative conditions, with applications in both in vitro enzyme assays and in vivo models of cholinergic dysfunction.

Research Area

Neuroscience

Key Properties

• CAS Number: 21133-52-8
• MW: 289.37
• Purity: 98.83%
• Formula: C₁₇H₂₃NO₃
• SMILES: [H][C@]12C[C@@H](O)CC[C@]11CCN(C)Cc3ccc(OC)c(O2)c13
• Target: Cholinesterase (ChE)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.91 mM);DMSO:27.5 mg/mL (95.03 mM)

Bioactivity

• In Vitro:
  Galanthamine, a recently isolated alkaloid, has been found to inhibit the acetylcholinesterase of muscle and the cholinesterase of plasma and brain. The inhibition of the muscle enzyme by galanthamine is greater than that produced by pyridostigmin, a compound of known usefulness, but less than that of neostigmin. The muscle cholinesterase inhibition produced by Lycoramine was found to be about equal to that of pyridostigmin.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

radiate, inhibit, Lycoramine, Lycoris, Inhibitor, galanthamine, acetylcholinesterase, AChE, dihydro-derivative, Cholinesterase (ChE)

Compound Identifiers

PubChem CID

443723