Ly93

SKU: orb1707031

Description

Ly93 is a potent, orally bioavailable inhibitor of sphingomyelin synthase 2 (SMS2), exhibiting an IC50 of 91 nM. It serves as a valuable research tool for investigating atherosclerosis in both cellular and animal models, aiding in the study of lipid metabolism and inflammatory pathways.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1883528-69-5
• MW: 332.4
• Purity: 99.88% (May vary between batches)
• Formula: C₂₁H₂₀N₂O₂
• SMILES: CCc1ccccc1COc1ccccc1C(=O)Nc1cccnc1
• Target: Phospholipase,Others
• Solubility: DMSO:80 mg/mL (240.67 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.93 mM)

Bioactivity

• In Vivo:
  Pharmacokinetic characterization of Ly93 conducted in C57BL/6J mice suggests oral efficacy of Ly93. As an effective selective SMS2 inhibitor, Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly reduced plasma SM levels in C57BL/6J mice.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ly93, Ly-93, SMS2

Compound Identifiers

PubChem CID

118911741