LY518674

SKU: orb1218035

Description

LY518674 decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα antagonist (EC50: 42 nM for human PPARα).

Key Properties

• CAS Number: 425671-29-0
• MW: 409.48
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₇N₃O₄
• SMILES: CC(C)(C(O)=O)Oc1ccc(CCCC(N2)=NN(Cc3ccc(C)cc3)C2=O)cc1
• Target: PPAR
• Solubility: DMSO:250 mg/mL (610.53 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  LY518674 reduces triglycerides and increased HDL-C In vivo. LY518674 substantially increases apolipoprotein A-I (apoA-I) turnover without major impact on steady-state levels of apoA-I or high-density lipoprotein-cholesterol (HDL-C).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY-674

Quick Database Links

Gene Symbol

PPAR