LY456236 free base

SKU: orb3174698

Description

LY456236 free base is a selective, non-competitive, orally active antagonist of the glutamate receptor 1 (mGlu1), effectively inhibiting phosphoinositide hydrolysis with an IC50 of 0.145 μM. Additionally, it inhibits EGFR with an IC50 of 0.918 μM. By suppressing the MAPK pathway, LY456236 free base blocks cell proliferation and counters the anti-apoptotic effects of DHPG. This compound is useful for seizure research.

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Key Properties

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CAS Number	338738-57-1
MW	281.32
Formula	C₁₆H₁₅N₃O₂
SMILES	N=1C=NC(NC2=CC=C(OC)C=C2)=C3C=C(OC)C=CC13
Target	p38 MAPK,Apoptosis,GluR,EGFR

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

p38 MAPK,Apoptosis,GluR,EGFR

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