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LY3405105

SKU: orb1218355

Description

1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester is a novel CDK7 inhibitors.

Images & Validation

Key Properties

CAS Number2326428-25-3
MW497.64
Purity>98% (HPLC)
FormulaC26H39N7O3
SMILESO=C(N1CCC(NC2=CC(C)=NC3=C(C(C)C)C=NN23)CC1)OC4CN(C(/C=C/CN(C)C)=O)CC4
TargetCDK
SolubilityDMSO:10 mM

Bioactivity

In Vitro
CDK7-IN-4 (compound I) exhibits significant inhibitory activity against NCI-H446, SNU-16, HCC1806, A2780, MCF7, HCT116, and NCI-H460 cells, with IC50 values of 0.01419, 0, 02312, 0.02553, 0.02651, 0.03201, 0.04601, and 0.0479, respectively.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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    2326428-25-3

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    25 mg, 100 mg, 200 mg, 5 mg, 50 mg, 1 mg, 10 mg
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Protocol Information

LY3405105 (orb1218355)

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% DMSO +
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% Tween 80 +
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Available Sizes

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200 mg
500 mg
2 mg
$ 110.00
5 mg
$ 160.00
10 mg
$ 240.00
25 mg
$ 440.00
50 mg
$ 640.00
100 mg
$ 900.00