LY3177833

SKU: orb1299485

Description

LY3177833 is a potent and selective inhibitor of Cdc7 kinase, exhibiting an IC50 of 3.3 nM. It is a valuable research tool for studying DNA replication and cell cycle progression in vitro, and has been investigated in preclinical cancer models in vivo.

Research Area

Cell Biology

Key Properties

• CAS Number: 1627696-51-8
• MW: 309.3
• Purity: 99.87%
• Formula: C₁₆H₁₂FN₅O
• SMILES: C[C@]1(NC(=O)c2cc(ccc12)-c1cn[nH]c1)c1ncncc1F
• Target: CDK
• Solubility: DMSO:30 mg/mL (96.99 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.47 mM)

Bioactivity

• Target IC50:
  CDC7:3.3 nM|pMCM2:290 nM
• In Vivo:
  LY-3177833 inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 μM). LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, LY 3177833, LY3177833, LY-3177833, CDK, Cdc7, Cyclin dependent kinase

Compound Identifiers

PubChem CID

81689696