LY3143921 hydrate

SKU: orb1298398

Description

LY3143921 hydrate is a potent and orally bioavailable CDC7 kinase inhibitor. It demonstrates broad-spectrum anticancer activity in vitro and has shown efficacy in preclinical in vivo tumor models, supporting its investigation in cancer research, particularly in DNA replication and cell cycle studies.

Research Area

Cell Biology

Key Properties

• CAS Number: 1627696-53-0
• MW: 327.31
• Purity: 98.43% (May vary between batches)
• Formula: C₁₆H₁₄FN₅O₂
• SMILES: C[C@]1(C2=C(C=C(C=C2)C3=CNN=C3)C(=O)N1)C4=NC=NC=C4F.O
• Target: CDK
• Solubility: DMSO:65 mg/mL (198.59 mM);Ethanol:32 mg/mL (97.77 mM)

Bioactivity

• Target IC50:
  Cdc7:3.3 nM|pMCM2:290 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDC7, LY 3143921 Hydrate, LY3143921 Hydrate, LY3143921 hydrate, LY-3143921 hydrate, LY-3143921 Hydrate

Compound Identifiers

PubChem CID

137794949