LY2922470

SKU: orb1308099

Description

LY2922470 is a potent and selective GPR40 agonist, demonstrating EC50 values of 7 nM (human), 1 nM (mouse), and 3 nM (rat). It significantly lowers glucose while increasing insulin and GLP-1 secretion, making it a valuable research tool for studying metabolic diseases in both in vitro and in vivo models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1423018-12-5
• MW: 475.6
• Purity: 93.34% (May vary between batches)
• Formula: C₂₈H₂₉NO₄S
• SMILES: COc1cccc2CCCN(Cc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)s3)c12
• Target: GPCR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.41 mM);DMSO:125 mg/mL (262.83 mM)

Bioactivity

• Target IC50:
  FFA1/GPR40:1 nM(EC50,mouse)|FFA1/GPR40:3 nM(EC50,rat)|FFA1/GPR40:7 nM(EC50, human)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FFAR, Free Fatty Acid Receptor, human GPR40, GPR40, Inhibitor, mouse GPR40, inhibit, LY 2922470, LY2922470, LY-2922470, rat GPR40

Compound Identifiers

PubChem CID

71257551