LY2457546

SKU: orb1741091

Description

LY2457546 is a potent, orally available multi-kinase inhibitor targeting VEGFR2, PDGFRβ, FLT-3, Tie-2, and Eph receptors. It demonstrates robust anti-tumor efficacy in vivo, inhibiting angiogenesis and causing regression in solid tumor and FLT3-ITD mutant AML xenograft models, supporting its advancement to clinical studies.

Key Properties

• CAS Number: 908265-94-1
• MW: 504.48
• Formula: C₂₈H₂₀F₄N₄O
• SMILES: FC=1C=C(C=2N3C(C=C(C=C3)C=4C=C(C)N=CC4)=NC2)C=CC1CC(NC5=CC(C(F)(F)F)=CC=C5)=O
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

60150606