LY2457546

SKU: orb1741091

Description

LY2457546 is a potent, orally available multi-kinase inhibitor targeting VEGFR2, PDGFRβ, FLT-3, Tie-2, and Eph receptors. It demonstrates robust anti-tumor efficacy in vivo, inhibiting angiogenesis and causing regression in solid tumor and FLT3-ITD mutant AML xenograft models, supporting its advancement to clinical studies.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 908265-94-1
• MW: 504.48
• Purity: 99.82% (May vary between batches)
• Formula: C₂₈H₂₀F₄N₄O
• SMILES: O=C(NC1=CC=CC(=C1)C(F)(F)F)CC2=CC=C(C=C2F)C3=CN=C4C=C(C=CN43)C=5C=CN=C(C5)C
• Target: Tyrosinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

60150606