LY2033298

SKU: orb1700050

Description

LY2033298 is a selective positive allosteric modulator of the muscarinic M4 receptor. It has been shown in vivo to potentiate the phase-shifting effects of oxotremorine on circadian rhythms in hamsters, supporting its research utility in neuroscience and neuropsychiatric disorders.

Research Area

Neuroscience

Key Properties

• CAS Number: 886047-13-8
• MW: 311.79
• Purity: 99.06%
• Formula: C₁₃H₁₄ClN₃O₂S
• SMILES: COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
• Target: AChR
• Solubility: DMSO:50 mg/mL (160.36 mM)

Bioactivity

• In Vivo:
  The M₄ positive allosteric modulator, LY2033298 (10-40 mg/kg), had no effect on light-induced phase shifts when administered alone, yet significantly enhanced (at 20 mg/kg) the inhibitory influence of oxotremorine on light-induced phase delays.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

M4 mAChR, LY2033298, LY-2033298, LY 2033298

Compound Identifiers

PubChem CID

11536903