Ly101-4B

SKU: orb3210389

Description

Ly101-4B is an apoptosis (apoptosis) inducer and multi-target inhibitor with antiproliferative, antitumor, and cytotoxic effects. It reduces HSF1 expression, inhibits microRNA-214 synthesis, and downregulates the expression of HSP27, HSP70, and HSP90. Additionally, Ly101-4B represses E2F-dependent transcriptional activity and downregulates its target genes. By decreasing DNA synthesis, inhibiting the cell cycle, and hindering the G1/S phase transition, Ly101-4B induces caspase3/7-mediated apoptosis without affecting RNA synthesis or causing necrosis. The compound demonstrates selectivity towards pancreatic ductal adenocarcinoma cells with varying genotypes and degrees of E2F dependency. Moreover, Ly101-4B is applicable in research related to epithelial ovarian cancer and pancreatic ductal adenocarcinoma.

Key Properties

• CAS Number: 1415728-94-7
• MW: 442.51
• Formula: C₂₃H₃₀N₄O₅
• SMILES: C(N)(=O)C=1N(N=C(C#CC2=CC=C(CCCCCCC)C=C2)N1)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• Target: HSP,DNA/RNA Synthesis,Early 2 Factor (E2F),Apoptosis,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HSP,DNA/RNA Synthesis,Early 2 Factor (E2F),Apoptosis,Caspase