LY-404039

SKU: orb1224398

Description

A potent, slective agonist of mGlu2 and mGlu3 receptors with Ki of 149 nM and 92 nM, respectively; displays >100-fold selectivity over other ionotropic glutamate receptors, glutamate transporters; suppresses electrically evoked excitatory activity in the striatum, and serotonin-induced l-glutamate release in the prefrontal cortex; reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats; oral bioavailable. Schizophrenia Phase 1 Clinical.

Key Properties

• CAS Number: 635318-11-5
• MW: 235.2145
• Purity: >98% (HPLC)
• Formula: C₇H₉NO₆S
• SMILES: O=S1(C[C@](C(O)=O)(N)[C@@H]2[C@@H](C(O)=O)[C@@H]21)=O
• Target: mGluR
• Solubility: DMSO:1 mg/mL;H2O:< 1 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY 2140023 | LY404039

Quick Database Links

Gene Symbol

mGluR