LY-3537982

SKU: orb1473163

Description

LY-3537982 (LY3537982) is a highly selective and potent KRAS-G12C inhibitor, selectively inhibits growth of KRAS G12C mutant cells (IC50=1-60 nM).LY-3537982 does not inhibit growth of KRAS G12S/G13C/G12D mutant cells and WT KRAS cells (CI50>10 uM).LY-3537982 displays high selectivity for proteome-wide cysteine residues was evaluated using competitive chemical proteomics (8866 peptides).LY3537982 inhibits the growth of subcutaneous EL3187 NSCLC PDX tumors in nude mice in a dose dependent manner.LY3537982 demonstrates robust tumor regression in combination with other agents in KRAS G12C in vivo models.LY3537982 is a promising KRAS G12C inhibitor predicted to deliver > 90% KRAS G12C target occupancy in the clinic.

Key Properties

• CAS Number: 2414198-64-2
• MW: 500.91
• Formula: C₂₃H₁₅CLF₂N₄O₃S
• SMILES: ClC1C(C2C=CC(=C3C=2C(C#N)=C(N)S3)F)=C(C=C2C=1OC[C@@]1([H])CN(C(C=C)=O)CN1C2=O)F

Storage & Handling

• Disclaimer: For research use only