LY 345899

SKU: orb1308092

Description

LY 345899 is a folate analog that potently inhibits methylenetetrahydrofolate dehydrogenase enzymes, with an IC50 of 96 nM for MTHFD2 and a Ki of 18 nM for MTHFD1. This inhibitor is a valuable research tool for studying one-carbon metabolism in cancer cell proliferation and has been utilized in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 10538-99-5
• MW: 471.42
• Purity: 99.69% (May vary between batches)
• Formula: C₂₀H₂₁N₇O₇
• SMILES: Nc1nc2NCC3CN(C(=O)N3c2c(=O)[nH]1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
• Target: DHFR
• Solubility: DMSO:60 mg/mL (127.28 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.24 mM)

Bioactivity

• Target IC50:
  MTHFD2:663 nM (Ki)|MTHFD1:18 nM (Ki)|MTHFD1:IC50 : 96 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY 345899, LY345899, LY-345899, Methylenetetrahydrofolate Dehydrogenase (MTHFD), inhibit, MTHFD1, Inhibitor

Compound Identifiers

PubChem CID

135484014