LY 303511 hydrochloride

SKU: orb1302872

Description

LY 303511 hydrochloride is a selective and potent small molecule inhibitor of the mTOR kinase. It is a valuable research tool for studying mTOR signaling pathways in both cellular and animal models of cancer, metabolic disorders, and aging-related research.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2070014-90-1
• MW: 342.82
• Purity: 98.47% (May vary between batches)
• Formula: C₁₉H₁₉ClN₂O₂
• SMILES: Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1
• Target: mTOR,Potassium Channel,TNF
• Solubility: DMSO:50 mg/mL (145.85 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.83 mM)

Bioactivity

• Target IC50:
  mTOR:
• In Vitro:
  LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. LY303511 acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY 303511, LY 303511 Hydrochloride, LY 303511 hydrochloride, LY303511, LY-303511, LY303511 hydrochloride, LY303511 Hydrochloride, LY-303511 Hydrochloride, KcsA, inhibit, mTOR, Inhibitor, TNFR, TNF Receptor, Potassium Channel, PotassiumChannel, Tumor Necrosis Factor Receptor

Compound Identifiers

PubChem CID

78357796