LY-2584702 tosylate salt

SKU: orb1307552

Description

LY-2584702 tosylate salt is a potent and selective ATP-competitive inhibitor of p70S6 kinase. It has been utilized in preclinical cancer research to investigate the role of the mTOR/S6K pathway in tumor growth, with studies conducted both in vitro and in vivo.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1082949-68-5
• MW: 617.62
• Purity: 98.87% (May vary between batches)
• Formula: C₂₈H₂₇F₄N₇O₃S
• SMILES: Cc1ccc(cc1)S(O)(=O)=O.Cn1cc(nc1C1CCN(CC1)c1ncnc2[nH]ncc12)-c1ccc(F)c(c1)C(F)(F)F
• Target: S6 Kinase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.62 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:12 mg/mL (19.43 mM)

Bioactivity

• Target IC50:
  p70 S6K:4 nM
• In Vivo:
  LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87 mg glioblastoma and HCT116 colon carcinoma xenograft models.
• In Vitro:
  In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY2584702, LY-2584702, LY2584702 tosylate, LY-2584702 Tosylate, LY2584702 tosylate salt, p70 S6K, LY 2584702 Tosylate, LY 2584702 tosylate salt, LY 2584702, S6 Kinase, S6Kinase, S6K, Ribosomal S6 Kinase (RSK)

Compound Identifiers

PubChem CID

46205871