LXRα agonist 1

SKU: orb3028154

Description

LXRα agonist 1 (Compound 40) is a selective activator of LXRα, with an EC50 of 42 nM, and also demonstrates some activation effects on LXRβ, with an EC50 of 266 nM. It promotes target gene transcription by stabilizing the ligand-binding domain (LBD) of LXRα. When combined with the Raf inhibitor Sorafenib, LXRα agonist 1 shows significant antitumor activity in liver cancer cells. This compound is applicable in research focused on lipotoxicity-related cancers.

Key Properties

• CAS Number: 1790089-97-2
• MW: 437.533
• Formula: C₂₈H₂₇N₃O₂
• SMILES: O=C1C(NC2=CC=C(C=C2)N3CCCCC3)=C(C=4C=CC=CC4)C(=O)N1CC=5C=CC=CC5
• Target: Liver X Receptor

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Liver X Receptor