LW1564

SKU: orb2814673

Description

LW1564 is a small molecule HIF-1α inhibitor (IC50=1.2 µM in HepG2 cells) that suppresses mitochondrial respiration and activates AMPK, leading to reduced cancer cell proliferation (GI50 0.4-4.6 µM) and antitumor efficacy in xenograft models. It is a useful research tool for studying hypoxia signaling, cancer metabolism, and lipid synthesis pathways in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2668337-39-9
• MW: 731.84
• Formula: C₄₂H₄₈F₃N₃O₅
• SMILES: O=C(N1CCN(CC2=CC=C(C=C2)C(F)(F)F)CC1)COC3=CC=C(C=C3)C45CC6CC(CC(C(=O)N7CC8=CC(OC)=C(OC)C=C8CC7)(C6)C4)C5
• Target: HIF/HIF Prolyl-Hydroxylase,AMPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156808999