LW106

SKU: orb3173437

Description

LW106 is a selective IDO1 inhibitor with an IC50 of 1.57 μM. It does not inhibit IDO2 and TDO. LW106 suppresses tumor growth by limiting substrate immune crosstalk and enriching cancer stem cells (CSC) within the tumor microenvironment. It reduces CSC subpopulations in xenograft tumors, leading to decreased tumor cell proliferation/invasiveness and inducing apoptosis. LW106 is applicable in research on lung cancer and melanoma.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 2116519-76-5
• MW: 245.24
• Formula: C₁₁H₁₁N₅O₂
• SMILES: ON=C(C1=NON=C1N)N2CC=3C=CC=CC3C2
• Target: Apoptosis,Indoleamine 2,3-Dioxygenase (IDO)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Indoleamine 2,3-Dioxygenase (IDO)