Luteolin

SKU: orb1224954

Description

Luteolin is a falconoid compound, which exhibits anticancer properties.(In Vitro):Luteolin (0-160 μM; 24 hours; NCI-H460 cells) treatment inhibits the viability of NCI-H460 cells in a concentration-dependent manner.Luteolin (20-80 μM; 24 hours; NCI-H460 cells) treatment causes an accumulation of cells in the S phase.Luteolin (320-580 μM; 48 hours; NCI-H460 cells) treatment induces apoptosis.Luteolin (20-80 μM; 24 hours; NCI-H460 cells) treatment increases the protein expression levels of apoptotic regulatory proteins, including the Bax/Bcl-2 ratio, in a concentration-dependent manner, however, only 80 μM Luteolin inhibits the expression of Bad. Luteolin also decreases the expression of Sirt1 in the NCI-H460 cell line in a concentration-dependent manner.(In Vivo):Luteolin (10-100 mg/kg; oral gavage; daily; for 12 weeks; adult male Wistar rats) has an antioxidant effect and can also protect against non-alcoholic steatohepatitis through targeting the pro-inflammatory IL-1 and Il-18 pathways in rats with a high carbohydrate/high fat diet.

Key Properties

• CAS Number: 491-70-3
• MW: 286.24
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₀O₆
• SMILES: O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13
• Target: PDE
• Solubility: Ethanol: 3 mg/mL warmed (10.48 mM); DMSO: 57 mg/mL (199.13 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRN 0292084 | Digitoflavone | Flacitran | Luteoline | Luteolol | Salifazide | Luteolin

Quick Database Links

Gene Symbol

PDE