Lusutrombopag

SKU: orb1296119

Description

Lusutrombopag (Mulpleta) is a small molecule agonist of the thrombopoietin receptor used to raise platelet counts in thrombocytopenic chronic liver disease patients before planned surgical procedures. Its research applications include in vitro studies of megakaryocyte proliferation and in vivo models of thrombocytopenia, supporting investigations into hematopoiesis and hemostasis management.

Research Area

Immunology & Inflammation, Protein Biochemistry

Key Properties

• CAS Number: 1110766-97-6
• MW: 591.55
• Purity: 99.96% (May vary between batches)
• Formula: C₂₉H₃₂Cl₂N₂O₅S
• SMILES: CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(\C=C(/C)C(O)=O)c(Cl)c3)n2)c1OC
• Target: Thrombopoietin Receptor,Thrombin
• Solubility: DMSO:30 mg/mL (50.71 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.38 mM)

Bioactivity

• In Vitro:
  Lusutrombopag is an agonist of the thrombopoietin receptor that activates platelet production. Lusutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes, thereby increasing platelet levels.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lusutrombopag, Mulpleta, inhibit, Inhibitor, Thrombopoietin Receptor, Thrombopoietin receptor, ThrombopoietinReceptor, S888711, S-888711, S 888711, TPO

Compound Identifiers

PubChem CID

49843517