Lupiwighteone

SKU: orb1297298

Description

Lupiwighteone is a bioactive small molecule with demonstrated anti-angiogenic, anticancer, and chemopreventive properties. Research, primarily in vitro using SH-SY5Y neuroblastoma cells, supports its potential for investigating cancer therapeutics and angiogenesis pathways.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 104691-86-3
• MW: 338.35
• Purity: 99.20% (May vary between batches)
• Formula: C₂₀H₁₈O₅
• SMILES: CC(C)=CCc1c(O)cc(O)c2c1occ(-c1ccc(O)cc1)c2=O
• Target: Apoptosis,Caspase,PARP,Bcl-2 Family
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (7.39 mM);DMSO:60 mg/mL (177.33 mM)

Bioactivity

• In Vitro:
  This study aimed to examine the antitumor activity of Lupiwighteone, explore its antitumor mechanism in a human prostate carcinoma cell line (DU-145), and evaluate its antiangiogenetic activity in the human umbilical vein endothelial cell line (HUVEC). The results showed that Lupiwighteone could inhibit the growth of DU-145 and HUVEC cells in a concentration-dependent and time-dependent manner by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Flow cytometry analysis indicated that Lupiwighteone could induce cell cycle arrest, cells apoptosis, mitochondrial membrane potential loss, and an increase in intracellular reactive oxygen species of DU-145 cells. Upregulation of Bax, cytochrome c, caspase-3, and PARP-1 protein expressions and downregulation of Bcl-2, procaspase-9, and p-Akt protein expressions were observed by western blot after the treatment of Lupiwighteone. Furthermore, the effects of Lupiwighteone on the cellular behavior of HUVECs were also investigated.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, 8-prenylgenistein, Bcl-2, antimicrobial, antioxidant, Apoptosis, Caspase, Lupiwighteone, PARP, inhibit, isoflavone, mTOR, Inhibitor, PI3K

Compound Identifiers

PubChem CID

5317480