Lupeol acetate

SKU: orb1684440

Description

Lupeol acetate, a bioactive derivative of Lupeol, exhibits oral activity and diverse pharmacological properties including anti-cancer, anti-inflammatory, and anti-diabetic effects. It demonstrates cytotoxicity against Hep-3B and A549 cell lines in vitro and inhibits rheumatoid arthritis in vivo by downregulating key inflammatory mediators such as TNF-α, IL-1β, and COX-2.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Neuroscience

Key Properties

• CAS Number: 1617-68-1
• MW: 468.75
• Purity: 99.84% (May vary between batches)
• Formula: C₃₂H₅₂O₂
• SMILES: C[C@]12[C@@]([C@@]3([C@@](C)(CC1)CC[C@H]3C(C)=C)[H])(CC[C@]4([C@@]2(C)CC[C@@]5([C@]4(C)CC[C@H](OC(C)=O)C5(C)C)[H])[H])[H]
• Target: Antifungal,TNF,COX,Parasite,Antibacterial,IL Receptor,Others,Interleukin
• Solubility: Ethanol:1 mg/mL (2.13 mM)

Bioactivity

• In Vivo:
  Methods: DBA/1J mice with collagen-induced arthritis (CIA) were randomly divided into three groups: vehicle, Lupeol acetate-treated (50mg/kg), and curcumin-treated (100mg/kg). The therapeutic effects were determined by clinical scores, expression levels of serum cytokines including TNF-α and IL-1β, (18)F-fluorodeoxyglucose ((18)F-FDG) microPET/CT, and histopathology. Results: In RA-bearing mice, the expression of inflammatory-related cytokines was suppressed, and LA improved clinical symptoms and bone erosion. Lupeol acetate also significantly reduced the accumulation of (18)F-FDG in the joints of RA-bearing mice. Lupeol acetate significantly improved the symptoms of RA by downregulating the expression of inflammatory cytokines and osteoclastogenesis.
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• In Vitro:
  Methods: Lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and bone marrow-derived macrophages (BMDM) were treated with Lupeol acetate (0-80μM) and TNF-α, IL-1β, COX-2, and MCP-1 were measured using Western blotting. In addition, bone formation was examined using reverse transcription-PCR (RT-PCR) and tartrate-resistant acid phosphatase (TRAP) staining. Results: Lupeol acetate inhibited the activation, migration, and formation of macrophage osteoclastogenesis in a dose-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TNF-α, 3-Acetyllupeol, Lupeol Acetate, Lupeyl acetate, NO Synthase, NOS

Compound Identifiers

PubChem CID

92157