lunresertib（RP-6306）

SKU: orb1910851

Description

RP-6306 is a selective inhibitor of PKMYT1 (Protein Kinase Membrane-Associated Tyrosine/Threonine 1), a key regulator of cell cycle progression. It was identified from patent WO2021195781A1 as compound 182. PKMYT1 is part of the DNA damage response pathway and plays a role in controlling the G2/M checkpoint, particularly in cells with disrupted cell cycle regulation, such as cancer cells. By inhibiting PKMYT1, RP-6306 can induce mitotic catastrophe and cell death in cancer cells, especially those with CCNE1 amplification or other dependencies on the G2/M checkpoint.

Key Properties

• CAS Number: 2719793-90-3
• MW: 324.377
• Purity: 0.98
• Formula: C₁₈H₂₀N₄O₂
• SMILES: O([H])C1C([H])=C([H])C(C([H])([H])[H])=C(C=1C([H])([H])[H])N1C(=C(C(N([H])[H])=O)C2C([H])=C(C([H])([H])[H])C(C([H])([H])[H])=NC1=2)N([H])[H]

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only