LUNA18

SKU: orb1911018

Description

LUNA18 is an 11-mer cyclic peptide inhibitor for the intracellular tough target RAS with Kd (KRAS/G12D) of 0.043 nM and cellular IC50 of 1.4 nM (AsPC-1). LUNA18 orally and dose-dependently exhibits potent anti-cancer activities in a mouse xenograft model. LUNA18 shows 21–47% oral bioavailability in animals such as mouse, rat, monkey, and dog and notably does not require special formulations.

Key Properties

• MW: 1437.71
• Purity: 0.98
• Formula: C₇₃H₁₀₅F₅N₁₂O₁₂
• SMILES: O=C(N(C)C)C[C@@H](C(N(C)[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N(C)[C@H]1C)=O)=O)=O)N(C)C([C@H](C2CCCC2)N(C)C(C3(CCCC3)NC([C@@](CCC4)([H])N4C([C@H](CCC5=CC(F)=C(C(F)(F)F)C(F)=C5)NC(CN(C)C([C@H](CC6=CC=C(C)C=C6)N(CC)C([C@@](CC7)([H])N7C1=O)=O)=O)=O)=O)=O)=O)=O

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

165413174