LUF6096

SKU: orb1685311

Description

LUF6096 (CF-602) is a selective allosteric enhancer of the adenosine A3 receptor, potentiating agonist binding with minimal orthosteric affinity. It has demonstrated cardioprotective efficacy in models of myocardial ischemia/reperfusion injury, supporting its research use in cardiovascular disease and receptor pharmacology studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1116652-18-6
• MW: 414.33
• Purity: 99.50%
• Formula: C₂₂H₂₁Cl₂N₃O
• SMILES: Clc1ccc(Nc2cc(NC(=O)C3CCCCC3)c3ccccc3n2)cc1Cl
• Target: Adenosine Receptor
• Solubility: DMSO:40 mg/mL (96.54 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.83 mM)

Bioactivity

• In Vivo:
  LUF6096 (twice i.v. bolus at 0.5 mg/kg or single i.v. bolus at 1 mg/kg) protects against myocardial ischemia/reperfusion injury in dogs.
• In Vitro:
  LUF6096 (10 μM; 30-120 min) reduces the dissociation rate of 125I-AB-MECA from the A3 receptor by 2.5 times in CHO cell membranes and, when pretreated for 15 min, significantly enhances the intrinsic activity of Cl-IB-MECA in inhibiting forskolin-stimulated cAMP production in CHO cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CF 602, CF602, CF-602, AdenosineReceptor, Adenosine receptor, Adenosine Receptor, LUF 6096, LUF6096, LUF-6096

Compound Identifiers

PubChem CID

25191023