Lucideric acid A

SKU: orb1297299

Description

Lucidenic acid A is a natural triterpenoid that modulates JNK and p38 MAPK signaling pathways. It has been shown in vitro to potentiate LPS-induced immune responses in human monocytic THP-1 cells, making it a useful research tool for studying inflammation and innate immunity.

Research Area

Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 95311-94-7
• MW: 458.59
• Purity: 99.89% (May vary between batches)
• Formula: C₂₇H₃₈O₆
• SMILES: [H][C@@]1(CC(=O)[C@@]2(C)C3=C(C(=O)C[C@]12C)[C@@]1(C)CCC(=O)C(C)(C)[C@]1([H])C[C@@H]3O)[C@H](C)CCC(O)=O
• Target: JNK,MMP,p38 MAPK
• Solubility: DMSO:60 mg/mL (130.84 mM)

Bioactivity

• In Vitro:
  Here, we showed that triterpenes-rich extract of antlered form of G. lucidum (G. lucidum AF) induces TNFα± production in monocytic THP-1 cells. Furthermore, the extract also synergized with lipopolysaccharide (LPS) to induce TNFα± production in THP-1 cells, suggesting an immunostimulatory role of triterpenes-rich extract of G. lucidum AF. Notably, the extract enhanced LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), while it suppressed LPS-induced phosphorylation of c-Jun N-terminal kinase (JNK) MAPK. p38 Inhibitor suppressed TNFα± production, while JNK inhibitor enhanced TNFα± production, implying that synergistic effect of the extract may work by modulating p38 and JNK MAPKs. Moreover, we found that the triterpenes-rich extract of G. lucidum AF contains high amounts of lucidenic acids. Lucidenic acid-A, -F and -D(2), which seem to dominantly exist in the extract, were purified from the triterpenes-rich extract. We also identified Lucidenic acid-A and -F as modulators of JNK and p38, respectively
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lucideric acid A, Lucidenic acid A, inhibit, JNK, p38MAPK, p38, p38 MAPK, MMP, MMP-9, Matrix metalloproteinases, Inhibitor

Compound Identifiers

PubChem CID

14109375