Lucidenic acid B

SKU: orb1684449

Description

Lucidenic acid B

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 95311-95-8
• MW: 474.59
• Purity: 98.00% (May vary between batches)
• Formula: C₂₇H₃₈O₇
• SMILES: C[C@]12C3=C([C@]4(C)[C@@](C[C@@H]3O)(C(C)(C)C(=O)CC4)[H])C(=O)[C@@H](O)[C@]1(C)[C@@]([C@@H](CCC(O)=O)C)(CC2=O)[H]
• Target: Apoptosis,Caspase

Bioactivity

• In Vitro:
  The effect of Lucidenic acids (A, B, C, and N) isolated from a new G. lucidum (YK-02) on the induction of cell apoptosis and the apoptotic pathway in HL-60 cells was investigated. The results demonstrated that Lucidenic acid B (LAB) did not affect the cell cycle profile; however, it increased the number of early and late apoptotic cells but not necrotic cells. Treatment of HL-60 cells with LAB caused loss of mitochondria membrane potential. Moreover, the ratio of expression levels of pro- and antiapoptotic Bcl-2 family members was changed by LAB treatment. LAB-induced apoptosis involved the release of mitochondria cytochrome c and subsequently induced the activation of caspase-9 and caspase-3, which were followed by cleavage of poly(ADP-ribose) polymerase (PARP).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PARP, Lucidenicacid B, Lucidenic acid B, Apoptosis, Bcl-2, Caspase, Caspase-3, Caspase-9

Compound Identifiers

PubChem CID

102410351