LTURM34

SKU: orb1308112

Description

LTURM34

Research Area

Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 1879887-96-3
• MW: 414.48
• Purity: 99.91%
• Formula: C₂₄H₁₈N₂O₃S
• SMILES: O=c1nc(oc2c(cccc12)-c1cccc2c3ccccc3sc12)N1CCOCC1
• Target: PI3K,PI4K,DNA-PK
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (7.96 mM);DMSO:60 mg/mL (144.76 mM)

Bioactivity

• Target IC50:
  PI4Kδ:8.5 μM|PI3Kβ:5.8 μM|DNA-PK:34 nM
• In Vitro:
  LTURM34 is more consistently active agains the selected cell lines (11 of 16), but at best shows 54% Inhibition agains the HOP-92 non-s All cell lung cancer line. LTURM34 displays effective Inhibition of DNA-PK with excellent selectivity ove the Class I PI3K isoforms IC50 : 5.8 and 8.5 μM for PI3K β and δ, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

inhibit, LTURM 34, LTURM34, LTURM-34, Inhibitor, DNA-dependent protein kinase, DNA-PK, DNAPK, PI3Kβ, PI3Kδ, PI4Kδ

Compound Identifiers

PubChem CID

122705987