LT-626

SKU: orb3173953

Description

LT-626 is a potent PARP inhibitor with an IC50 of 1.60 nM. It effectively inhibits the synthesis of intracellular PAR, with an IC50 of 17.9 nM, and exhibits increased cytotoxicity in colorectal cancer cells harboring MRE11 mutations. In colorectal cancer cells, LT-626 shows synergistic effects when combined with Cisplatin, Oxaliplatin, and SN-38. This compound is applicable for studying colorectal cancer.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1207456-03-8
• MW: 379.37
• Formula: C₂₀H₁₅F₂N₅O
• SMILES: CN1C([C@H]2C=3C4=C(N[C@@H]2C5=CC=C(F)C=C5)C=C(F)C=C4C(=O)NN3)=NC=C1
• Target: PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PARP