LSN3074753

SKU: orb2663641

Description

LSN3074753 is a pan-RAF and RAF dimer inhibitor that suppresses MAPK pathway activation in tumors driven by BRAF monomers or RAF dimers, such as colorectal cancers with BRAF or KRAS mutations. It shows additive/synergistic effects with Cetuximab in colorectal cancer PDX models, supporting its research use in both in vitro and in vivo oncology studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1455031-68-1
• MW: 439.53
• Formula: C₂₄H₃₀FN₅O₂
• SMILES: CC=1C(=CC2=C(N1)C=C(NC)N=C2)C3=CC(NC(NC[C@H](C(C)(C)C)O)=O)=C(F)C=C3C
• Target: Kras,Raf,Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

89827799