LSKL TFA

SKU: orb1679211

Description

LSKL TFA is a blood-brain barrier permeable TGF-β1 antagonist derived from LAP. It functions by inhibiting the TSP-1/LAP interaction, thereby blocking TGF-β1 activation. This mechanism has demonstrated efficacy in preclinical models of subarachnoid hemorrhage, renal fibrosis, and liver fibrosis.

Research Area

Immunology & Inflammation, Stem Cell & Developmental Biology

Key Properties

• Target: TGF-beta/Smad
• CAS Number: 2828433-17-4
• MW: 572.62
• Purity: 99.33% (May vary between batches)
• Formula: C₂₃H₄₃F₃N₆O₇
• SMILES: O=C(O)C(F)(F)F.CC(C)C[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H](CO)NC([C@@H](N)CC(C)C)=O)=O)=O

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LSKL, Inhibitor of Thrombospondin (TSP 1) (TFA), LSKL, Inhibitor of Thrombospondin (TSP-1), LSKL, Inhibitor of Thrombospondin (TSP1) (TFA), LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA), H-Leu-Ser-Lys-Leu-NH2 TFA, H-Leu-Ser-Lys-Leu-NH2 TFA(283609-79-0 TFA), TGF-β1, TGF-β/Smad, TGF-β Receptor, TGFβ, TGFbeta/Smad, TGF-b/Smad, TGFb, TGFbeta, TGF-beta, Smad

Compound Identifiers

PubChem CID

145707571