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LSD1-IN-34

SKU: orb2664105

Description

LSD1-IN-34 is a potent, orally bioavailable dual inhibitor of LSD1 (IC50=4.51 nM) and MAO-A (IC50=18.46 nM). It suppresses Ang II-induced cardiac fibroblast activation and TGFβ/Smad signaling, demonstrating efficacy in a murine heart failure model with a favorable rat PK profile and low cytotoxicity.

Research Area

Epigenetics & Chromatin, Metabolism Research, Neuroscience, Stem Cell & Developmental Biology

Images & Validation

Key Properties

TargetMonoamine Oxidase,Histone Demethylase,TGF-beta/Smad

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information