LRE1

SKU: orb1707050

Description

LRE1 is a potent, selective, and allosteric inhibitor of soluble adenylyl cyclase (sAC). This research tool is valuable for investigating cAMP signaling pathways in both cellular (in vitro) and animal (in vivo) models, particularly in studies of sperm motility, mitochondrial function, and pH regulation.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1252362-53-0
• MW: 280.78
• Purity: >99.99% (May vary between batches)
• Formula: C₁₂H₁₃ClN₄S
• SMILES: Nc1nc(Cl)cc(n1)N(Cc1cccs1)C1CC1
• Target: Adenylate cyclase
• Solubility: DMSO:112.5 mg/mL (400.67 mM)

Bioactivity

• In Vitro:
  LRE1 prevents sAC-dependent processes in cellular and physiological systems and facilitates exploration of the therapeutic potential of sAC inhibition. LRE1 binds to the bicarbonate activator binding site and suppresses soluble adenylyl cyclase (sAC) via a unique allosteric mechanism.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LRE 1, LRE1, LRE-1, Adenylyl cyclase, Adenylyl cyclase (AC), Adenylylcyclase

Compound Identifiers

PubChem CID

47279808