LPA2 antagonist 1

SKU: orb1707051

Description

LPA2 antagonist 1 is a potent and selective inhibitor of the lysophosphatidic acid receptor 2 (LPA2). This small molecule tool compound is valuable for investigating LPA2-mediated signaling pathways in both cellular assays and animal models of fibrosis, cancer, and neuropathic pain.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1017606-66-4
• MW: 500.47
• Purity: 99.85% (May vary between batches)
• Formula: C₂₀H₂₃Cl₂N₅O₂S₂
• SMILES: N([C@H](CN1CCN(S(=O)(=O)C2=CC(Cl)=C(Cl)C=C2)CC1)C)C3=C4C(C(C)=CS4)=NC=N3
• Target: LPA Receptor,LPL Receptor
• Solubility: DMF:80 mg/mL (159.85 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (6.59 mM);DMSO:80 mg/mL (159.85 mM)

Bioactivity

• Target IC50:
  LPA2:17 nM
• In Vitro:
  LPA2 antagonist 1 inhibits LPA-induced Erk phosphorylation in a concentration-dependent manner. LPA2 antagonist 1 inhibits the proliferation of HCT-116 colon cancer cells induced by LPA in a dose-dependent manner.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LPA2, LPA2 antagonist 1, LPA-2 antagonist 1

Compound Identifiers

PubChem CID

24882686