Lp-PLA2-IN-1

SKU: orb1308114

Description

Lp-PLA2-IN-1 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). This compound is a valuable research tool for investigating the enzyme's role in inflammatory processes, with applications in studying atherosclerosis and neurodegenerative diseases like Alzheimer's in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1420367-28-7
• MW: 468.38
• Purity: 99.60% (May vary between batches)
• Formula: C₂₁H₁₇F₅N₄O₃
• SMILES: CN1CCCn2c1cc(OCc1cc(F)c(Oc3ccc(nc3)C(F)(F)F)c(F)c1)nc2=O
• Target: Phospholipase
• Solubility: Ethanol:20 mg/mL (42.7 mM)

Bioactivity

• In Vitro:
  Lp-PLA2 is a phospholipase A2 enzyme involved in the hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2 travels with LDL and rapidly cleaves oxidized phosphatidylcholine molecules derived from the oxidation of LDL.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Lp-PLA2, Lp-PLA2 -IN-1, Lp-PLA2 inhibitor 1, LpPLA2IN1, Lp-PLA-2-IN-1, Lp-PLA2-IN-1, Lp PLA2 IN 1, Inhibitor, Phospholipase

Compound Identifiers

PubChem CID

71236597