LP-922761

SKU: orb1707054

Description

LP-922761 is a potent, selective, and orally bioavailable inhibitor of both AAK1 and BIKE kinases. This small molecule is a valuable research tool for investigating clathrin-mediated endocytosis and BMP signaling in cellular and animal models of neurological disorders and pain.

Research Area

Neuroscience

Key Properties

• CAS Number: 1454808-95-7
• MW: 410.47
• Purity: 99.98% (May vary between batches)
• Formula: C₂₁H₂₆N₆O₃
• SMILES: CN(CCNc1ccc2ncc(-c3ccc(cc3)C(N)=O)n2n1)C(=O)OC(C)(C)C
• Target: AAK1,AAK1 (AP2 associated kinase 1)
• Solubility: DMSO:1 mg/mL (2.44 mM)

Bioactivity

• Target IC50:
  AAK1:7.6 nM (cell assays)|AAK1:4.8 nM (enzyme assays)|BIKE:24 nM
• In Vivo:
  In mice, the brain-to-plasma ratio of LP-922761 was 0.007, indicating that LP-922761 was basically confined to the peripheral compartment.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AP2 associated kinase 1, AP2associatedkinase1, BIKE, AAK1, AAK1(AP2associatedkinase1), AAK1 (AP2 associated kinase 1), LP922761, LP-922761, LP 922761

Compound Identifiers

PubChem CID

86696405