LP-922056

SKU: orb1303622

Description

LP-922056 is a potent and selective inhibitor of Notum Pectinacetylesterase, demonstrating EC50 values of 21 nM for human and 55 nM for mouse enzymes. This small molecule is a valuable research tool for investigating Wnt signaling modulation in both cellular and animal models of bone regeneration and metabolic disorders.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1365060-22-5
• MW: 300.78
• Purity: 99.91% (May vary between batches)
• Formula: C₁₁H₉ClN₂O₂S₂
• SMILES: OC(=O)CSc1ncnc2c(C3CC3)c(Cl)sc12
• Target: Wnt/beta-catenin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.3 mM);DMSO:120 mg/mL (398.96 mM)

Bioactivity

• Target IC50:
  Notum Pectinacetylesterase (human):21 nM (EC50)|Notum Pectinacetylesterase (mouse):55 nM (EC50)
• In Vivo:
  In mice, LP-922056 (3, 10, 30 mg/kg; gavage) significantly increases midshaft femur cortical bone thickness. LP-922056 (10 mg/kg) achieved high Cmax of 129 μM and AUC of 1533 μM•h while volume of distribution is 0.13 L/kg and low clearance is 0.49 mL/min•kg. LP-922056 (10 mg/kg; oral) increases cortical bone thickness and strength in the midshaft femur, bone mass in the femoral neck, and vertebral body cortical shell.
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• In Vitro:
  LP-922056 can be used as a complementary chemical tool for exploring the role of Notum in Wnt signaling.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

thickness, Wnt, Wnt/betacatenin, Wnt/b-catenin, Wnt/β-catenin, βcatenin, betacatenin, beta-catenin, cortical, bone, bcatenin, Inhibitor, femur, lipase, Notum, LP922056, LP-922056, LP 922056, inhibit, orally, Pectinacetylesterase, midshaft

Compound Identifiers

PubChem CID

56932967