LP-533401 hydrochloride

SKU: orb1707055

Description

LP-533401 hydrochloride is a peripherally restricted tryptophan hydroxylase (Tph) inhibitor that reduces peripheral 5-hydroxytryptamine synthesis. It serves as a research tool for investigating conditions like periodontal disease and hepatic steatosis in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1040526-12-2
• MW: 562.94
• Purity: 98.00% (May vary between batches)
• Formula: C₂₇H₂₃ClF₄N₄O₃
• SMILES: Cl.N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2ccc(cc2)-c2cccc(F)c2)C(F)(F)F)nc(N)n1)C(O)=O
• Target: Hydroxylase,5-HT Receptor
• Solubility: H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.55 mM);DMSO:15 mg/mL (26.65 mM)

Bioactivity

• In Vivo:
  LP-533401 hydrochloride (250, 100, 10 mg/kg) prevented and rescued ovariectomized mice from osteoporosis .
• In Vitro:
  LP-533401 hydrochloride (0.1-1 μM; 3 days) completely inhibited serotonin production in RBL2H3 cells.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5HT Receptor, 5-HT, 5HTReceptor, LP-533401 Hydrochloride, Tryptophan hydroxylase 1

Compound Identifiers

PubChem CID

102602704