LOXL2/sGC modulator-1

SKU: orb3173919

Description

LOXL2/sGC modulator-1 (Compound 11k) is an LOXL2 inhibitor with an IC₅₀ of 0.13 μM and acts as an sGC activator. It shows good selectivity for LOX (IC₅₀ > 45.9 μM) and LOXL3 (IC₅₀ = 1.30 μM). In the presence of the gGC inhibitor ODQ, it significantly increases intracellular cGMP levels. LOXL2/sGC modulator-1 effectively inhibits hypoxia-induced collagen deposition and cross-linking while promoting vasodilation. This compound is useful for researching pulmonary arterial hypertension.

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Key Properties

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Target	Guanylate cyclase,Monoamine Oxidase

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Guanylate cyclase,Monoamine Oxidase

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