Lotamilast

SKU: orb1303472

Description

Lotamilast (RVT-501) is a potent and selective PDE-4 inhibitor with an IC50 of 2.8 nM. It is a research compound investigated for treating inflammatory skin conditions like atopic dermatitis, with studies exploring its anti-inflammatory effects in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 947620-48-6
• MW: 472.49
• Purity: 99.29% (May vary between batches)
• Formula: C₂₆H₂₄N₄O₅
• SMILES: CNc1nc(-c2cccc(NC(=O)c3ccc(cc3)C(=O)OC)c2)c2cc(OC)c(OC)cc2n1
• Target: PDE
• Solubility: DMSO:50 mg/mL (105.82 mM)

Bioactivity

• Target IC50:
  PDE4:2.8 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Lotamilast, PDE4, Inhibitor, E6005, E-6005, E 6005, RVT 501, RVT501, RVT-501, Phosphodiesterase (PDE), phosphodiesterase

Compound Identifiers

PubChem CID

24864553