Losartan Carboxylic Acid

SKU: orb1304181

Description

Losartan Carboxylic Acid (E-3174) is the active metabolite of losartan and a highly potent AT1 receptor antagonist (Kis: 0.57 nM rat, 0.67 nM human). It effectively inhibits angiotensin II-induced vasoconstriction, producing depressor and vasodilatory effects, making it a key tool for cardiovascular research in both in vitro and in vivo studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 124750-92-1
• MW: 436.89
• Purity: 99.28% (May vary between batches)
• Formula: C₂₂H₂₁ClN₆O₂
• SMILES: C(N1C(CCCC)=NC(Cl)=C1C(O)=O)C2=CC=C(C=C2)C3=C(C=CC=C3)C=4NN=NN4
• Target: RAAS,Drug Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.58 mM);DMSO:70 mg/mL (160.22 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

pressor, responses, smooth, vascular, anterior, angiotensin II, Angiotensin Receptor, AT1 receptor, E 3174, E3174, E-3174, cells, infarction, muscle, myocardial, Losartan Carboxylic Acid, inhibit, metabolite, EXP3174, EXP-3174, EXP 3174, Inhibitor

Compound Identifiers

PubChem CID

108185