Losartan Carboxaldehyde

SKU: orb1299460

Description

Losartan Carboxaldehyde is a selective cyclooxygenase-2 (COX-2) inhibitor that acts on the vascular endothelium. It is a research tool used in vitro and in vivo to study COX-2's role in inflammation, blood pressure regulation, and endothelial function.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 114798-36-6
• MW: 420.89
• Purity: 99.12% (May vary between batches)
• Formula: C₂₂H₂₁ClN₆O
• SMILES: CCCCc1nc(Cl)c(C=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
• Target: COX
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.38 mM);DMSO:4.21 mg/mL (10 mM)

Bioactivity

• In Vitro:
  At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-inflammatory, AT1-R–blocking, DuP 167, DuP167, DuP-167, Cyclooxygenase, COX, COX-2, EXP 3179, EXP3179, EXP-3179, Inhibitor, intermediate aldehyde metabolite, inhibit, Losartan, Losartan Carboxaldehyde

Compound Identifiers

PubChem CID

9802264