Lornoxicam

SKU: orb1308547

Description

Lornoxicam is a potent oxicam-class NSAID with analgesic, anti-inflammatory, and antipyretic effects, distinguished by its strong inhibition of prostaglandin synthesis. It is utilized in research models for studying pain and inflammation, supported by in vivo and in vitro pharmacological studies. The compound is approved for clinical use in Japan.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 70374-39-9
• MW: 371.82
• Purity: >99.99% (May vary between batches)
• Formula: C₁₃H₁₀ClN₃O₄S₂
• SMILES: CN1C(C(=O)NC2=NC=CC=C2)=C(O)C2=C(C=C(Cl)S2)S1(=O)=O
• Target: TNF,NO Synthase,Prostaglandin Receptor,COX,Apoptosis,Endogenous Metabolite,Interleukin
• Solubility: DMSO:10 mg/mL (26.89 mM)

Bioactivity

• Target IC50:
  COX-1:5 nM|COX-2:8 nM
• In Vivo:
  Lornoxicam dose relatedly reduces the total number of c-Fos-LI neurons with the strongest effect corresponding to the 75% reduction for the highest dose of 9 mg/kg, and the 45% reduction for the low dose of 0.3 mg/kg. Lornoxicam (0.1, 0.3 mg/kg, 1 mg/kg, 3 mg/kg and 9 mg/kg, i.v.) significantly reduces the number of c-Fos-LI neurons in both superficial (24%, 33%, 53%, 54%, and 63% reduction, respectively) and deep (28%, 48%, 62%, 69% and 79% reduction, respectively) laminae of the dorsal horn of the spinal cord. Lornoxicam reduces hyperalgesia with an effective dose that provides 50% inhibition (ED50) of 0.083 mg/kg, 3.9 mg/kg and 4.3 mg/kg respectively in a chronic rat model of arthritis. Lornoxicam significantly reduces the PGE2 level in paw exudate and the cerebrospinal fluid in rats. Lornoxicam 0.16 mg/kg, celecoxib 4 mg/kg and loxoprofen 2.4 mg/kg significantly reduces hyperalgesia to a similar extent in acute oedematous rats.
• In Vitro:
  Lornoxicam is as effective as the opioid analgesics morphine, pethidine (meperidine) and tramadol in relieving postoperative pain following gynaecological or orthopaedic surgery, and as effective as other NSAIDs after oral surgery. Lornoxicam is also as effective as other NSAIDs in relieving symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ro 13-9297, TS 110, TS110, TS-110, EndogenousMetabolite, Inhibitor, inhibit, Lornoxicam, Cyclooxygenase, COX-1, COX-2, Endogenous Metabolite, Chlortenoxicam, COX

Compound Identifiers

PubChem CID

54690031