Loratadine

SKU: orb1309786

Description

Loratadine

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 79794-75-5
• MW: 382.88
• Purity: 99.71%
• Formula: C₂₂H₂₃ClN₂O₂
• SMILES: CCOC(=O)N1CC\C(CC1)=C1/C2=C(CCC3=C1N=CC=C3)C=C(Cl)C=C2
• Target: Influenza Virus,Histamine Receptor,Anti-infection
• Solubility: DMSO:25 mg/mL (65.29 mM);Ethanol:77 mg/mL (201.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.22 mM)

Bioactivity

• Target IC50:
  B(0)AT2:4 μM
• In Vivo:
  Loratadine blocks Kv1.5 channels in a concentration-, voltage-, time-, and use-dependent manner when expressed in human Ltk-cells transfected with the hKv1.5 channel gene at concentrations exceeding therapeutic plasma levels. It also inhibits rhinovirus-induced upregulation of ICAM-1 in main bronchial or transformed respiratory epithelial cells. Identified as a selective inhibitor of B(0)AT 2 with an IC50 of 4 μM, loratadine exhibits low or no activity against several other members of the SLC6 family. Pre-incubation with loratadine concentration-dependently suppresses the release of histamine and LTC4 in human FcεRI+ cells upon challenge with Der p1 antigen or anti-FcεRI. In human umbilical vein endothelial cells, loratadine significantly inhibits histamine-induced secretion of IL-6 and IL-8, with its active metabolites showing even stronger effects. Additionally, loratadine in a dose-dependent manner inhibits the mRNA of ICAM-1 induced by rhinovirus infection and completely suppresses the activation of the rhinovirus-induced ICAM-1 promoter.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

B(0)AT2, Loratadine, Loratidine, Influenza Virus, InfluenzaVirus, inhibit, Inhibitor, Histamine Receptor, HistamineReceptor, SCH 29851, SCH29851, SCH-29851

Compound Identifiers

PubChem CID

3957