Lopinavir

SKU: orb1225807

Description

Lopinavir (also known as ABT-378) is a highly potent inhibitor of human immunodeficiency virus (HIV) protease that potently inhibits wild-type and mutant HIV protease.(In Vitro):HIV-1 protease is an essential enzyme for production of mature, infective virus.Lopinavir potently inhibits wild-type and mutant HIV protease (Ki= 1.3 to 3.6 pM), blocks the replication of laboratory and clinical strains of HIV type 1 (EC50=0.006 to 0.017 μM), and maintains high potency against mutant HIV selected by Ritonavir in vivo (EC50=≤0.06 μM).(In Vivo):Coadministration with low-dose Ritonavir significantly improves the pharmacokinetic properties and hence the activity of Lopinavir against HIV-1 protease.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 192725-17-0
• MW: 628.8
• Purity: >98% (HPLC)
• Formula: C₃₇H₄₈N₄O₅
• SMILES: CC1=C(C(=CC=C1)C)OCC(=O)N[C@@H](CC2=CC=CC=C2)[C@H](C[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)N4CCCNC4=O)O
• Target: HIV
• Solubility: Ethanol: 126 mg/mL (200.38 mM); DMSO: 126 mg/mL (200.38 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A-157378.0 | ABT-378

Quick Database Links

Gene Symbol

HIV