Lonidamine

SKU: orb1224917

Description

Lonidamine is an orally administered small molecule hexokinase inactivator.(In Vitro):Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells.Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation.Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion.Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities.Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells.(In Vivo):Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model.

Key Properties

• CAS Number: 50264-69-2
• MW: 321.17
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₀Cl₂N₂O₂
• SMILES: O=C(C1=NN(CC2=CC=C(Cl)C=C2Cl)C3=C1C=CC=C3)O
• Target: hexokinase
• Solubility: DMSO: 64 mg/mL (199.27 mM)

Bioactivity

• In Vivo:
  Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model. Animal model: Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model. Dosage: 10, 30, 100 mg/kg/day. Administration: Oral administration, daily, d10 to d20 after BLM treatment. Result: Partially or completely reversed the increases in HK2 and lactate induced by BLM and reduced the expression of 10 profibrotic mediators.
• In Vitro:
  Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells. Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation. Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion. Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities. Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AF 1890 | DICA | Diclondazolic Acid

Quick Database Links

Gene Symbol

hexokinase