Lomitapide Mesylate

SKU: orb1702238

Description

Lomitapide Mesylate (BMS-201038 mesylate) is the mesylate salt form of lomitapide, a potent and selective small-molecule inhibitor of microsomal triglyceride transfer protein (MTP). It is widely used in biochemical research to investigate lipid metabolism, including in vitro enzyme assays and in vivo models of dyslipidemia and homozygous familial hypercholesterolemia.

Research Area

Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 202914-84-9
• MW: 789.83
• Purity: 99.92% (May vary between batches)
• Formula: C₄₀H₄₁F₆N₃O₅S
• SMILES: CS(O)(=O)=O.FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c2ccccc2-c2ccccc12
• Target: MTP,MTP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.06 mM);DMSO:122 mg/mL (154.46 mM);Ethanol:93 mg/mL (117.75 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  MTP:8 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MTP, Lomitapide, Lomitapide Mesylate, Inhibitor, inhibit, BMS 201038, BMS 201038 Mesylate, BMS201038, BMS-201038, BMS201038 Mesylate, BMS-201038 mesylate, BMS-201038 Mesylate, AEGR733, AEGR-733, AEGR733 Mesylate, AEGR-733 mesylate, AEGR-733 Mesylate, AEGR 733, AEGR 733 Mesylate

Compound Identifiers

PubChem CID

11274333