Lomerizine

SKU: orb1300648

Description

Lomerizine dihydrochloride

Research Area

Neuroscience

Key Properties

• CAS Number: 101477-54-7
• MW: 541.46
• Purity: >98%
• Formula: C₂₇H₃₀F₂N₂O₃·2HCl
• SMILES: Cl.Cl.COc1ccc(CN2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)c(OC)c1OC
• Target: Ion channel
• Solubility: Soluble in DMSO (> 45 mg/ml) or in Ethanol (up to 30 mg/mL)

Bioactivity

• In Vivo:
  Treatment of rat retinal neurons cultured in vitro with 0.1 μM and 1 μM Lomerizine significantly reduced glutamate-induced neurotoxicity.1 μM Lomerizine showed a protective effect against N-methyl-D-aspartic acid- and haemonucleic acid-induced types of neurotoxicity in cultured rat retinal neurons.
• In Vitro:
  Treatment of rat retinal neurons cultured in vitro with 0.1 μM and 1 μM Lomerizine significantly reduced glutamate-induced neurotoxicity.1 μM Lomerizine showed a protective effect against N-methyl-D-aspartic acid- and haemonucleic acid-induced types of neurotoxicity in cultured rat retinal neurons.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KB-2796

Compound Identifiers

PubChem CID

122125