Lomerizine dihydrochloride

SKU: orb1300648

Description

Lomerizine dihydrochloride

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 101477-54-7
• MW: 541.46
• Purity: 99.80%
• Formula: C₂₇H₃₀F₂N₂O₃·2HCl
• SMILES: Cl.Cl.COc1ccc(CN2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)c(OC)c1OC
• Target: Calcium Channel
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:15 mg/mL (27.7 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.69 mM);Ethanol:49 mg/mL (90.5 mM)

Bioactivity

• In Vivo:
  Treatment of rat retinal neurons cultured in vitro with 0.1 μM and 1 μM Lomerizine significantly reduced glutamate-induced neurotoxicity.1 μM Lomerizine showed a protective effect against N-methyl-D-aspartic acid- and haemonucleic acid-induced types of neurotoxicity in cultured rat retinal neurons.
• In Vitro:
  Treatment of rat retinal neurons cultured in vitro with 0.1 μM and 1 μM Lomerizine significantly reduced glutamate-induced neurotoxicity.1 μM Lomerizine showed a protective effect against N-methyl-D-aspartic acid- and haemonucleic acid-induced types of neurotoxicity in cultured rat retinal neurons.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CalciumChannel, Ca2+ channels, Calcium Channel, Ca channels, Inhibitor, KB2796, KB-2796, KB 2796, Lomerizine, Lomerizine 2HCl, Lomerizine dihydrochloride, Lomerizine Dihydrochloride, Lomerizine Hydrochloride, Lomerizine hydrochloride, inhibit, L-type calcium channel, Terranas, T-type calcium channel

Compound Identifiers

PubChem CID

122125