Lodoxamide tromethamine

SKU: orb1308120

Description

Lodoxamide tromethamine

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 63610-09-3
• MW: 553.91
• Purity: 99.58%
• Formula: C₁₉H₂₈ClN₅O₁₂
• SMILES: NC(CO)(CO)CO.NC(CO)(CO)CO.OC(=O)C(=O)Nc1cc(cc(NC(=O)C(O)=O)c1Cl)C#N
• Target: Histamine Receptor
• Solubility: DMSO:15 mg/mL (27.08 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.61 mM)

Bioactivity

• In Vivo:
  In Ascaris-sensitized anesthetized rhesus monkeys, Lodoxamide tromethamine significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge. The addition of Lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution increases oxygenation, decreases microvascular permeability, and increases compliance thereby decreasing lung reperfusion injury.
• In Vitro:
  In purified rat peritoneal mast cells, Lodoxamide tromethamine inhibits ionophore-induced 45Ca influx with associated histamine release. Lodoxamide tromethamine significantly and dose-dependently inhibits the chemotactic response of eosinophils to fMLP and to IL-5. Lodoxamide tromethamine strongly inhibits the release of eosinophil peroxidase after IgA-dependent activation and inhibits the release of eosinophil cationic protein and eosinophil-derived neurotoxin to a lesser extent.

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Histamine Receptor, Histamine relase, HistamineReceptor, Lodoxamide tromethamine, U-42585E

Compound Identifiers

PubChem CID

11192129